Shimizu H, Nagata C, Tsuchiya E, Nakagawa K, Weng S Y
Department of Public Health, Gifu University School of Medicine.
Jpn J Cancer Res. 1994 Dec;85(12):1196-9. doi: 10.1111/j.1349-7006.1994.tb02929.x.
To evaluate the effect of cigarette smoking on lung cancer by tumor location and histological type, we compared the smoking history obtained from medical records of 605 patients with squamous cell carcinoma (194 males and 10 females) or adenocarcinoma (219 males and 182 females) of the lung and 183 patients with metastatic lung cancer (82 males and 101 females) who had been aged 40 years or over at the time of surgical resection at the Cancer Institute in Tokyo from 1973-1991. The tumors which developed in a main or segmental bronchus were classified as central type, and those in a subsegmental or more distal bronchi were categorized as peripheral type. Cases with adenocarcinoma were classified by a pathologist into two histological subtypes, papillary and tubular types, according to the WHO lung carcinoma classification. Risk of squamous cell carcinoma was strongly associated with cigarette smoking for both central (OR (odds ratio) = 10.3 in males and 4.4 in females) and peripheral sites (OR = 10.7 in males and 6.5 in females). There was no significant association between cigarette smoking and adenocarcinoma for any tumor site or histological subtype in both sexes.
为了根据肿瘤位置和组织学类型评估吸烟对肺癌的影响，我们比较了从东京癌症研究所1973年至1991年期间接受手术切除时年龄在40岁及以上的605例肺鳞状细胞癌患者（194例男性和10例女性）或腺癌患者（219例男性和182例女性）以及183例转移性肺癌患者（82例男性和101例女性）的病历中获取的吸烟史。发生在主支气管或段支气管的肿瘤被分类为中央型，而发生在亚段支气管或更远端支气管的肿瘤被分类为周围型。根据世界卫生组织肺癌分类，腺癌病例由病理学家分为两种组织学亚型，乳头状和管状类型。鳞状细胞癌的风险与吸烟在中央部位（男性OR（比值比）=10.3，女性OR=4.4）和周围部位（男性OR=10.7，女性OR=6.5）均密切相关。吸烟与两性中任何肿瘤部位或组织学亚型的腺癌均无显著关联。
