Osann K E, Anton-Culver H, Kurosaki T, Taylor T
Clinical Cancer Center, University of California, Irvine 92717.
Int J Cancer. 1993 Apr 22;54(1):44-8. doi: 10.1002/ijc.2910540108.
The importance of cigarette smoking as a risk factor for specific histologic types of lung cancer in men and women has been examined in a case-control analysis of data from the Cancer Surveillance Program of Orange County, a population-based registry. Smoking habits were abstracted from medical records for 1153 men and 833 women diagnosed with primary lung cancer in 1984-1986 and 1851 men and 1656 women aged 30 or older diagnosed with cancers not associated with smoking. Ninety-six percent of men and 89% of women with lung cancer were current or former cigarette smokers, as compared with 55% of men and 34% of women with other cancers. The age and ethnicity-adjusted odds ratios (OR) for ever-smoking were 19.7 for men and 15.0 for women. Men and women who smoked 2 or more packs per day experienced nearly equal risks. Comparison of the most common cell types showed that women smokers had equal or lower ORs for squamous-cell carcinoma and adenocarcinoma, but higher OR for small-cell carcinoma, as compared with men smokers. While the smoking-associated OR were equal for small-cell and squamous-cell carcinomas in men, the OR for women were significantly higher for small-cell carcinoma than for squamous-cell carcinoma.
在一项基于人群登记的橙县癌症监测项目数据的病例对照分析中，研究了吸烟作为男性和女性特定组织学类型肺癌风险因素的重要性。从1984年至1986年诊断为原发性肺癌的1153名男性和833名女性以及1851名30岁及以上诊断为与吸烟无关癌症的男性和1656名女性的医疗记录中提取吸烟习惯。患肺癌的男性中有96%、女性中有89%是当前或曾经吸烟者，相比之下，患其他癌症的男性中有55%、女性中有34%是吸烟者。经年龄和种族调整后的曾经吸烟的比值比（OR），男性为19.7，女性为15.0。每天吸烟2包或更多包的男性和女性面临几乎相同的风险。对最常见细胞类型的比较表明，与男性吸烟者相比，女性吸烟者患鳞状细胞癌和腺癌的OR相同或更低，但患小细胞癌的OR更高。虽然男性中小细胞癌和鳞状细胞癌与吸烟相关的OR相同，但女性中小细胞癌与吸烟相关的OR显著高于鳞状细胞癌。
