蛋白酪氨酸激酶pp60v-src的抑制剂：来自厚刺蛇尾的甾醇硫酸盐。
Inhibitors of protein tyrosine kinase pp60v-src: sterol sulfates from the brittle star Ophiarachna incrassata.
作者信息
Fu X, Schmitz F J, Lee R H, Papkoff J S, Slate D L
机构信息
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
出版信息
J Nat Prod. 1994 Nov;57(11):1591-4. doi: 10.1021/np50113a023.
PMID:7853009
Abstract
Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp60v-src inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All five compounds were found to inhibit protein tyrosine kinase pp 60v-src.
摘要
采用蛋白酪氨酸激酶pp60v-src抑制试验，对绿蛇尾Ophiarachna incrassata提取物进行生物活性导向分离，得到一种新的硫酸甾醇[2]以及四种已知的硫酸甾醇（1、3 - 5）。发现所有五种化合物均能抑制蛋白酪氨酸激酶pp60v-src。
相似文献
1
Inhibitors of protein tyrosine kinase pp60v-src: sterol sulfates from the brittle star Ophiarachna incrassata.蛋白酪氨酸激酶pp60v-src的抑制剂：来自厚刺蛇尾的甾醇硫酸盐。
J Nat Prod. 1994 Nov;57(11):1591-4. doi: 10.1021/np50113a023.
2
The marine natural product, halistanol trisulfate, inhibits pp60v-src protein tyrosine kinase activity.海洋天然产物三硫酸哈利斯坦醇可抑制pp60v-src蛋白酪氨酸激酶活性。
Biochem Biophys Res Commun. 1994 Aug 30;203(1):260-4. doi: 10.1006/bbrc.1994.2176.
3
Marine sponge polyketide inhibitors of protein tyrosine kinase.
Biochem Biophys Res Commun. 1992 Apr 30;184(2):765-72. doi: 10.1016/0006-291x(92)90656-6.
4
New cycloartanol sulfates from the alga Tydemania expeditionis: inhibitors of the protein tyrosine kinase pp60v-src.
J Nat Prod. 1994 Jan;57(1):74-8. doi: 10.1021/np50103a010.
5
Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors.星形孢菌素、UCN - 01和钙泊三醇作为蛋白激酶抑制剂的应用及特异性
Methods Enzymol. 1991;201:340-7. doi: 10.1016/0076-6879(91)01030-6.
6
7
Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases.
J Med Chem. 1994 Mar 4;37(5):598-609. doi: 10.1021/jm00031a009.
8
The use of Rous sarcoma virus transformation mutants with differing tyrosine kinase activities to study the relationships between vinculin phosphorylation, pp60v-src location and adhesion plaque integrity.利用具有不同酪氨酸激酶活性的劳氏肉瘤病毒转化突变体来研究纽蛋白磷酸化、pp60v-src定位与黏着斑完整性之间的关系。
Exp Cell Res. 1986 Jul;165(1):216-28. doi: 10.1016/0014-4827(86)90546-x.
9
pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.pp60v-src酪氨酸激酶在注射了劳氏肉瘤病毒的无肉瘤禽胚胎中表达并具有活性。
Proc Natl Acad Sci U S A. 1988 Oct;85(20):7587-91. doi: 10.1073/pnas.85.20.7587.
10
A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases.一种与p60v-src的137至157位残基相对应的合成肽可抑制酪氨酸特异性蛋白激酶。
Biochem Biophys Res Commun. 1990 Sep 28;171(3):1152-9. doi: 10.1016/0006-291x(90)90805-w.
引用本文的文献
1
Disulfated Ophiuroid Type Steroids from the Far Eastern Starfish and Their Cytotoxic Activity on the Models of 2D and 3D Cultures.远东海星中的二硫酸基海胆甾醇类甾体化合物及其在二维和三维培养模型中的细胞毒性活性。
Mar Drugs. 2022 Feb 24;20(3):164. doi: 10.3390/md20030164.
2
Synthesis and antiviral activity of sulfated and acetylated derivatives of 2beta,3alpha-dihydroxy-5alpha-cholestane.2β,3α-二羟基-5α-胆甾烷的硫酸化和乙酰化衍生物的合成及其抗病毒活性
Steroids. 2003 Feb;68(2):125-32. doi: 10.1016/s0039-128x(02)00166-6.
Zotero 插件