一种新型细胞毒性大环内酯类化合物——超斯托利德B，它与超斯托利德A相关，从新喀里多尼亚海洋海绵新管海绵中分离得到。
A novel cytotoxic macrolide, superstolide B, related to superstolide A, from the New Caledonian marine sponge Neosiphonia superstes.
作者信息
D'Auria M V, Gomez Paloma L, Minale L, Zampella A, Debitus C
机构信息
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
出版信息
J Nat Prod. 1994 Nov;57(11):1595-7. doi: 10.1021/np50113a024.
The structure of a new cytotoxic macrolide, superstolide B [1], isolated from the deep water sponge Neosiphonia superstes, collected off New Caledonia, was elucidated mainly on the basis of nmr data. Compound 1 is closely related to superstolide A [2], a major cytotoxic component isolated from that organism, but lacks the 25-hydroxyl group found in 2 and has a C-24 (C-25)-double bond.
从新喀里多尼亚近海采集的深水海绵Neosiphonia superstes中分离出一种新的细胞毒性大环内酯类化合物——超斯托利德B [1]，其结构主要根据核磁共振数据得以阐明。化合物1与从该生物体中分离出的主要细胞毒性成分超斯托利德A [2]密切相关，但缺少2中存在的25-羟基，且具有一个C-24（C-25）双键。
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