Yabuuchi K, Minami M, Katsumata S, Yamazaki A, Satoh M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Brain Res Mol Brain Res. 1994 Oct;26(1-2):135-42. doi: 10.1016/0169-328x(94)90084-1.
Expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain after transient forebrain ischemia was investigated by in situ hybridization histochemistry. Thirty min after the start of recirculation, IL-1 beta mRNA was induced in the several brain regions, including the olfactory bulb, cerebral cortex, hippocampus, striatum and thalamus where neuronal degeneration was reported to be observed after transient forebrain ischemia. The hybridization signals were observed both on the glial cells and around the vascular walls.
通过原位杂交组织化学法研究了短暂性前脑缺血后大鼠脑中白细胞介素-1β（IL-1β）mRNA的表达。再灌注开始30分钟后，IL-1β mRNA在几个脑区被诱导表达，包括嗅球、大脑皮层、海马、纹状体和丘脑，据报道短暂性前脑缺血后这些脑区会出现神经元变性。在神经胶质细胞和血管壁周围均观察到杂交信号。
