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通过人体攻毒试验评估疫苗效力。

Assessment of vaccine efficacy by challenge studies in man.

作者信息

Tyrrell D A

出版信息

Postgrad Med J. 1976 Jun;52(608):379-80. doi: 10.1136/pgmj.52.608.379.

DOI:10.1136/pgmj.52.608.379
PMID:785429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2496319/
Abstract

The only final test of the potency of a vaccine is its ability to protect against exposure in an epidemic. Laboratory tests for control purposes attempt to predict this capacity. It is suggested that challenging small groups of volunteers with attenuated influenza virus is a good index of immunity which could be used to check and refine present tests and to evaluate new ones.

摘要

疫苗效力的唯一最终检验是其在疫情中预防接触的能力。出于控制目的的实验室检测试图预测这种能力。有人认为,用减毒流感病毒对一小群志愿者进行激发试验是一种很好的免疫指标,可用于检验和完善现有检测方法,并评估新的检测方法。

相似文献

1
Assessment of vaccine efficacy by challenge studies in man.通过人体攻毒试验评估疫苗效力。
Postgrad Med J. 1976 Jun;52(608):379-80. doi: 10.1136/pgmj.52.608.379.
2
[1st experience with human inoculations with an inactivated influenza vaccine].
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引用本文的文献

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Model answers or trivial pursuits? The role of mathematical models in influenza pandemic preparedness planning.标准答案还是琐碎之事?数学模型在流感大流行防范规划中的作用。
Influenza Other Respir Viruses. 2007 Mar;1(2):43-54. doi: 10.1111/j.1750-2659.2007.00008.x.
2
The response to inactivated influenza A (H3N2) vaccines: the development and effect of antibodies to the surface antigens.甲型流感病毒(H3N2)灭活疫苗的反应:针对表面抗原的抗体的产生及效果
J Hyg (Lond). 1977 Jun;78(3):363-75. doi: 10.1017/s0022172400056266.

本文引用的文献

1
Potentiation of the antibody response to inactivated A2-Hong Kong vaccines by previous heterotypic influenza virus infection.
Microbios. 1973 Sep-Oct;8(30):101-10.
2
Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2-Hong Kong-68 (H 3 N 2 ) influenza vaccines. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines.接种减毒活疫苗、去污剂裂解疫苗和油佐剂A2-香港-68(H3N2)流感疫苗的志愿者的抗体反应及对攻击的抵抗力。提交给医学研究理事会流感及其他呼吸道病毒疫苗委员会的报告。
J Hyg (Lond). 1972 Sep;70(3):531-43. doi: 10.1017/s0022172400063117.
3
A comparison of live and killed influenza-virus vaccines. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines.活流感病毒疫苗与灭活流感病毒疫苗的比较。提交给医学研究委员会流感及其他呼吸道病毒疫苗委员会的报告。
Lancet. 1968 Aug 24;2(7565):418-22. doi: 10.1016/s0140-6736(68)90463-7.
4
Immunity following intranasal administration of an inactivated, freeze-dried A/England/42/72 vaccine.经鼻内接种灭活冻干A/英格兰/42/72疫苗后的免疫反应。
Arch Virol. 1975;48(4):307-16. doi: 10.1007/BF01317429.