通过人体攻毒试验评估疫苗效力。
Assessment of vaccine efficacy by challenge studies in man.
作者信息
Tyrrell D A
出版信息
Postgrad Med J. 1976 Jun;52(608):379-80. doi: 10.1136/pgmj.52.608.379.
Abstract
The only final test of the potency of a vaccine is its ability to protect against exposure in an epidemic. Laboratory tests for control purposes attempt to predict this capacity. It is suggested that challenging small groups of volunteers with attenuated influenza virus is a good index of immunity which could be used to check and refine present tests and to evaluate new ones.
摘要
疫苗效力的唯一最终检验是其在疫情中预防接触的能力。出于控制目的的实验室检测试图预测这种能力。有人认为，用减毒流感病毒对一小群志愿者进行激发试验是一种很好的免疫指标，可用于检验和完善现有检测方法，并评估新的检测方法。
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本文引用的文献
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Potentiation of the antibody response to inactivated A2-Hong Kong vaccines by previous heterotypic influenza virus infection.
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