Smith A F, Davies J R
J Hyg (Lond). 1977 Jun;78(3):363-75. doi: 10.1017/s0022172400056266.
A controlled trial of influenza vaccines in a boys' public school from November 1970 to October 1975 provided an opportunity to study the response to vaccine and the effect on subsequent natural challenge in boys with differing natural experience of influenza A strains. The response to influenza A (H3N2) vaccines was assessed by estimating homotypic and heterotypic antibodies to the surface antigens. Previous natural experience of influenza A was found to influence vaccine response and the effect of natural challenge. The antibody response to revaccination with the same strain showed a progressively poorer response to second and third doses. The protectitive effect of naturally acquired and vaccine-induced antibodies was assessed during two outbreaks of influenza A which occurred in the trial period.
1970年11月至1975年10月在一所男子公立学校进行的流感疫苗对照试验，为研究不同甲型流感病毒自然感染经历的男孩对疫苗的反应以及对随后自然感染的影响提供了机会。通过估计针对表面抗原的同型和异型抗体来评估对甲型（H3N2）流感疫苗的反应。发现先前甲型流感的自然感染经历会影响疫苗反应和自然感染的效果。用同一毒株再次接种时的抗体反应显示，第二剂和第三剂的反应逐渐变差。在试验期间发生的两次甲型流感暴发期间，评估了自然获得的抗体和疫苗诱导的抗体的保护作用。
