Swanson R V, Alex L A, Simon M I
Division of Biology, California Institute of Technology, Pasadena 91125.
Trends Biochem Sci. 1994 Nov;19(11):485-90. doi: 10.1016/0968-0004(94)90135-x.
Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.
自磷酸化组氨酸激酶和应答调节结构域构成了双组分信号系统的基本组成部分。这些系统利用独特的磷酸转移化学机制来调节细菌生理学的许多方面。现在在真核生物中也发现了同源系统。尽管它们具有共同的磷酸转移机制，但双组分系统在其结构域的排列上表现出广泛的多样性，并且在不同信号转导回路中的作用具有灵活性。
