Perrimon N, Desplan C
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115.
Trends Biochem Sci. 1994 Nov;19(11):509-13. doi: 10.1016/0968-0004(94)90140-6.
An elegant combination of genetic and biochemical approaches has been used to investigate a variety of signal transduction pathways in developmental processes. Here, we describe the 'terminal' signaling system in the Drosophila embryo, which is responsible for pattern formation in the polar regions of the embryo. This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors.
遗传方法和生化方法的巧妙结合已被用于研究发育过程中的各种信号转导途径。在这里，我们描述果蝇胚胎中的“末端”信号系统，该系统负责胚胎极性区域的模式形成。这条信号通路涉及一种膜结合受体酪氨酸激酶（RTK），它与其他果蝇RTK（如七less）以及哺乳动物RTK（如表皮生长因子或血小板衍生生长因子受体）相似。
