Pabst R, Binns R M
Medical School of Hannover, Germany.
Vet Immunol Immunopathol. 1994 Oct;43(1-3):151-6. doi: 10.1016/0165-2427(94)90131-7.
Although the lung is not a lymphoid organ it contains large numbers of lymphocytes. These can be found in different compartments: (1) the pulmonary intravascular pool, which is organ-specific and shows a unique migration pattern; (2) the interstitial lymphocyte pool, which is equivalent in size to the whole blood pool; (3) the bronchus-associated lymphoid tissue (BALT) which develops as a result of microbial stimulation; (4) the intraepithelial and lamina propria lymphocytes of the bronchi, with their typical subset composition; (5) the lymphocytes in the bronchoalveolar space, which can be sampled by bronchoalveolar lavage. The size and kinetics of the lymphocyte pools have been studied in the pig in more detail than in most other species. Despite this organotypic compartmentalisation of the pulmonary lymphoid cells in the pig, the lung is part of the integrated mucosal immune system, as shown by protective oral immunisation against the lung-pathogenic bacteria Actinobacillus pleuropneumoniae. The lung immune system in the pig is not only of veterinary interest, but also a relevant model for the human respiratory tract.
尽管肺不是淋巴器官，但它含有大量淋巴细胞。这些淋巴细胞可存在于不同的区域：（1）肺血管内池，具有器官特异性并呈现独特的迁移模式；（2）间质淋巴细胞池，其大小与全血池相当；（3）支气管相关淋巴组织（BALT），它是微生物刺激的结果；（4）支气管的上皮内和固有层淋巴细胞，具有典型的亚群组成；（5）支气管肺泡腔内的淋巴细胞，可通过支气管肺泡灌洗进行采样。与大多数其他物种相比，猪的淋巴细胞池的大小和动力学得到了更详细的研究。尽管猪的肺淋巴细胞存在这种器官特异性的分隔，但肺是整合黏膜免疫系统的一部分，针对肺致病性细菌胸膜肺炎放线杆菌的保护性口服免疫就证明了这一点。猪的肺免疫系统不仅在兽医领域具有重要意义，也是人类呼吸道的一个相关模型。
