Eguchi F, Shindo M, Emoto M, Mohtai H, Hachisuga T, Kawarabayashi T, Shirakawa K
Dept. of Obstetrics and Gynecology, School of Medicine, Fukuoka University.
Gan To Kagaku Ryoho. 1995 Feb;22(2):233-7.
The antiemetic efficacy of a combination of granisetron and clonazepam was investigated in 39 gynecological cancer patients treated with cisplatin. Granisetron (3 mg/body/day) was administered by intravenous drip infusion before and 24 hours after anticancer drug administration, and clonazepam was taken orally twice a day. With a combination of granisetron and clonazepam, excellent efficacy was found in 87% (34/39) of the cases. Delayed emesis occurred in 38% (13/34), but the degree of nausea was mild. Clinically, antiemetic therapy with a combination of granisetron and clonazepam demonstrated superior antiemetic effects and seems to be useful for controlling nausea and vomiting associated with cancer chemotherapy.
对39例接受顺铂治疗的妇科癌症患者研究了格拉司琼与氯硝西泮联合使用的止吐效果。格拉司琼（3mg/体/天）在抗癌药物给药前及给药后24小时静脉滴注，氯硝西泮每日口服两次。格拉司琼与氯硝西泮联合使用时，87%（34/39）的病例疗效极佳。38%（13/34）出现延迟性呕吐，但恶心程度较轻。临床上，格拉司琼与氯硝西泮联合进行止吐治疗显示出卓越的止吐效果，似乎有助于控制与癌症化疗相关的恶心和呕吐。
