Tanioka Y, Fujii T, Nakata N, Nakagawa H, Tanimoto H, Kioka H, Naito H
Dept. of Obstetrics and Gynecology, Chugoku District Cancer Center, Kure National Hospital.
Gan To Kagaku Ryoho. 1994 Dec;21(16):2803-8.
Twenty-three patients with gynecological cancer who were treated with 85 cycles of cytotoxic chemotherapy containing platinum received intravenous granisetron repeatedly. Granisetron (3 mg/body) was drip-infused twice for each cycle at a 24-hour interval. The antiemetic efficacy was evaluated and compared for each day and each cycle, and analysed using the chi-square and H tests. There were no significant differences between the first cycle and the subsequent second through fifth cycles in the severity of nausea and the frequency of vomiting. The latter tended to increase in the second day of each cycle. These results indicated that granisetron does not decrease in antiemetic efficacy by repeated administration during multiple cycles of anti-cancer chemotherapy.
23例接受含铂细胞毒性化疗85个周期治疗的妇科癌症患者反复接受静脉注射格拉司琼治疗。格拉司琼（3mg/人）在每个周期以24小时间隔静脉滴注两次。对每天和每个周期的止吐效果进行评估和比较，并采用卡方检验和H检验进行分析。在恶心严重程度和呕吐频率方面，第一个周期与随后的第二至第五个周期之间没有显著差异。后者在每个周期的第二天有增加的趋势。这些结果表明，在多周期抗癌化疗期间重复给药，格拉司琼的止吐效果不会降低。
