Hoff H F
Stroke. 1976 Jul-Aug;7(4):390-3. doi: 10.1161/01.str.7.4.390.
Apolipoproteins from human plasma high density (HDL), low density (LDL) and very low density lipoproteins (VLDL) were visualized in human arteries employing immunofluorescence techniques. Comparison between the localization patterns in extracranial and intracranial arteries and those in coronary arteries and the aorta was made. ApoA-I from HDL, apoB from LDL, and apoC-III from VLDL, as well as neutral lipid, were all localized to connective tissue and extracellular lipid pools in atherosclerotic lesions, and only to areas of intimal thickening in grossly "uninvolved" arteries. The degree of superposition of localizations was similiar in each vascular bed, and within the error resulting from the structural changes due to the focal nature of the atherosclerotic process. These results suggest a broad specificity in localization of apolipoproteins in most arterial lesions, and suggest that no differences in apolipoprotein accumulation exist between extracranial and intracranial arteries, coronary arteries, or the aorta. Variations in prevalence for atherosclerosis in each arterial bed must be accounted for on other bases.
利用免疫荧光技术，在人体动脉中观察了来自人血浆高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）的载脂蛋白。对颅外和颅内动脉以及冠状动脉和主动脉中的定位模式进行了比较。来自HDL的载脂蛋白A-I、来自LDL的载脂蛋白B和来自VLDL的载脂蛋白C-III，以及中性脂质，均定位于动脉粥样硬化病变中的结缔组织和细胞外脂质池，并且仅定位于大体上“未受累”动脉的内膜增厚区域。在每个血管床中，定位叠加的程度相似，且在动脉粥样硬化过程的局灶性导致的结构变化所产生的误差范围内。这些结果表明，在大多数动脉病变中，载脂蛋白定位具有广泛的特异性，并且表明颅外和颅内动脉、冠状动脉或主动脉之间在载脂蛋白积累方面不存在差异。每个动脉床中动脉粥样硬化患病率的差异必须基于其他因素来解释。
