Albert R K, Sbarbaro J A, Hudson L D, Iseman M
Am Rev Respir Dis. 1976 Oct;114(4):699-704. doi: 10.1164/arrd.1976.114.4.699.
The outcome of 81 patients receiving supervised ambulatory treatment with twice-weekly isoniazid and ethambutol is reported. The patients were divided into 2 groups, one of which received its entire outpatient treatment with isoniazid and ethambutol, the other receiving isoniazid and ethambutol after initial treatment with isoniazid and streptomycin. In both groups, there was a 100 per cent favorable response at completion of therapy and no relapes detected among those patients followed after treatment. We compared our results with other studies of intermittent-supervised therapy and concluded that twice-weekly isoniazid and ethambutol given up to 18 months after an adequate phase of daily treatment is a highly effective and well-tolerated regimen.
报告了81例接受每周两次异烟肼和乙胺丁醇监督下门诊治疗患者的治疗结果。患者被分为两组，一组全程接受异烟肼和乙胺丁醇门诊治疗，另一组在先用异烟肼和链霉素初始治疗后再接受异烟肼和乙胺丁醇治疗。两组在治疗结束时均有100%的良好反应，且在治疗后随访的患者中未发现复发情况。我们将我们的结果与其他间歇监督治疗研究进行了比较，并得出结论，在每日治疗的充分阶段后给予长达18个月的每周两次异烟肼和乙胺丁醇是一种高效且耐受性良好的治疗方案。
