Thiele B, Brink I, Ploch M
Medizinische Fakultät (Charité) der Humboldt Universität zu Berlin, Germany.
J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S60-2. doi: 10.1177/089198879400700116.
The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.
在全血培养系统中对金丝桃提取物LI 160对刺激细胞因子表达的影响进行了体外研究。从五名健康志愿者和四名抑郁症患者采集血样。在微量滴定板上孵育24小时后，定量测定白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的释放。发现PHA刺激的金丝桃提取物对白细胞介素-6的释放有显著抑制作用。讨论了其与金丝桃提取物抗抑郁作用的可能关系。
