通过荧光原位杂交对人、大鼠和小鼠1β型蛋白磷酸酶催化亚基基因（PPP1CB）进行染色体定位。
Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.
作者信息
Saadat M, Kakinoki Y, Mizuno Y, Kikuchi K, Yoshida M C
机构信息
Section of Biochemistry, Faculty of Science, Hokkaido University, Sapporo, Japan.
出版信息
Jpn J Genet. 1994 Dec;69(6):697-700. doi: 10.1266/jjg.69.697.
Using fluorescent in situ hybridization (FISH) method, gene encoding the catalytic subunit of protein phosphatase type 1 beta (PPP1CB) in human and its corresponding gene in rat (PP1 delta) and mouse (dis2m2) were mapped to human 2p23, rat 6q21-q23, and mouse 12D, respectively. These results indicate that PPP1CB is a member of conserved syntenic group. It is shown that the genes encoding catalytic subunit of protein phosphatase type 1 family (PP1 alpha, PP1 beta, and PP1 gamma in human and those corresponding genes in rat and mouse), in spite of their high identity, are located to different chromosomes in these three species.
采用荧光原位杂交（FISH）方法，将人类蛋白磷酸酶1β型催化亚基（PPP1CB）的编码基因及其在大鼠中的对应基因（PP1δ）和小鼠中的对应基因（dis2m2）分别定位到人类2p23、大鼠6q21 - q23和小鼠12D。这些结果表明PPP1CB是保守同线群的成员。结果显示，蛋白磷酸酶1家族催化亚基的编码基因（人类中的PP1α、PP1β和PP1γ以及大鼠和小鼠中的对应基因），尽管它们具有高度同源性，但在这三个物种中位于不同的染色体上。
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