Saadat M, Nakamura K, Mizuno Y, Kikuchi K, Yoshida M C
Department of Biology, Faculty of Science, Shiraz University, Iran.
Jpn J Genet. 1995 Dec;70(6):669-74. doi: 10.1266/jjg.70.669.
Protein tyrosine phosphatases (PTPases) negatively regulate the effect(s) of protein tyrosine kinases and are implicated in the regulation of a variety of biological events including cell activation, differentiation, and neoplastic transformation. To gain insight into the role(s) of the PTPases, we mapped the gene encoding for the widely expressed receptor-like protein tyrosine phosphatase PTP alpha/LRP (locus symbol Ptpra) to rat chromosome 3q36 and mouse chromosome 2G by fluorescence in situ hybridization method. These results indicate that there is a conserved syntenic group between human 20p13, rat 3q36, and mouse 2G.
蛋白酪氨酸磷酸酶（PTPases）对蛋白酪氨酸激酶的作用起负调控作用，并参与包括细胞激活、分化和肿瘤转化在内的多种生物学事件的调控。为深入了解PTPases的作用，我们通过荧光原位杂交法将广泛表达的受体样蛋白酪氨酸磷酸酶PTPα/LRP（基因座符号Ptpra）的编码基因定位到大鼠染色体3q36和小鼠染色体2G上。这些结果表明，人类20p13、大鼠3q36和小鼠2G之间存在保守的同线群。
