Lee H C
Department of Physiology, University of Minnesota, Minneapolis 55455.
Cell Signal. 1994 Aug;6(6):591-600. doi: 10.1016/0898-6568(94)90042-6.
Cyclic nucleotides are second messengers exerting their cellular effects mainly through protein phosphorylation. A new member of this family, cyclic ADP-ribose, is involved, instead, in mediating mobilization of Ca+2 from internal stores. The structure of this nucleotide has now been determined by X-ray crystallography and accumulating evidence indicates it may be an endogenous modulator of the Ca+2 induced Ca+2 release mechanism. This article summarizes the current knowledge of the structure, the mechanism of action and the metabolic enzymes of this novel nucleotide. With this new addition, the signalling functions of the cyclic nucleotide family are now extended from protein phosphorylation to Ca+2 signalling.
环核苷酸是第二信使，主要通过蛋白质磷酸化发挥其细胞效应。相反，该家族的一个新成员环ADP核糖参与介导细胞内钙库中Ca²⁺的释放。这种核苷酸的结构现已通过X射线晶体学确定，越来越多的证据表明它可能是Ca²⁺诱导的Ca²⁺释放机制的内源性调节剂。本文总结了关于这种新型核苷酸的结构、作用机制和代谢酶的当前知识。随着这一新成员的加入，环核苷酸家族的信号传导功能现在从蛋白质磷酸化扩展到了Ca²⁺信号传导。
