Meyer M
Z Allg Mikrobiol. 1976;16(4):279-82. doi: 10.1002/jobm.3630160407.
The mutagenesis in phage T7 after MMS-, HNO2-, hydroxylamine-, 5-BUdR-, and 2-AP-treatment in relation to host controlled functions is investigated. There was no dependence of the induction of mutations on the character of the host strains (rec, hcr). A back mutation system (amber system) and a forward mutation system (host range system) have been used. Substances which cause mainly transitions from GC to AT do not lead or only rarely lead to reversions of the amber system; but chemicals producing transitions from AT to GC do so.
研究了经甲基磺酸甲酯（MMS）、亚硝酸（HNO2）、羟胺、5-溴尿嘧啶核苷（5-BUdR）和2-氨基嘌呤（2-AP）处理后，噬菌体T7中的诱变作用与宿主控制功能的关系。突变的诱导与宿主菌株的特性（rec，hcr）无关。使用了一个回复突变系统（琥珀突变系统）和一个正向突变系统（宿主范围系统）。主要引起从GC到AT转换的物质不会导致或仅很少导致琥珀突变系统的回复；但引起从AT到GC转换的化学物质则会导致回复。
