Jia Z, Koike K, Nikaido T, Ohmoto T, Ni M
Department of Pharmacognosy, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Chem Pharm Bull (Tokyo). 1994 Nov;42(11):2309-14. doi: 10.1248/cpb.42.2309.
Two novel triterpenoid saponins, ardisicrenoside C (1) [3 beta-O-(alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)- [beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl)-16 alpha, 28-dihydroxy-olean-12-en-30-oic acid 30-O-beta-D-glucopyranosyl ester] and ardisicrenoside D (2) [3 beta-O-(beta-D-xylopyranosyl-(1-->2)- beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl)-16 alpha, 28-dihydroxy-olean-12-en-30-oic acid 30-O-beta-D-glucopyranosyl ester] were isolated from the roots of Ardisia crenata. Structure assignments are based on spectroscopic data including 2D-NMR (correlation spectroscopy (COSY), homonuclear Hartmann-Hahn spectroscopy (HOHAHA), heteronuclear correlated spectroscopy (HETCOR), heteronuclear multiple bond correlation (HMBC) and rotating frame NOE spectroscopy (ROESY)) experiments and some chemical reactions. In addition, the isolated saponins along with their prosapogenins and sapogenins have been evaluated for their inhibitory activity on cAMP phosphodiesterase as a primary screening test for new medicinal compounds.
从朱砂根的根部分离出两种新型三萜皂苷，即朱砂根皂苷C（1）[3β-O-（α-L-鼠李糖基-（1→2）-β-D-葡萄糖基-（1→4）-[β-D-葡萄糖基-（1→2）]-α-L-阿拉伯糖基）-16α，28-二羟基-齐墩果-12-烯-30-酸30-O-β-D-葡萄糖酯]和朱砂根皂苷D（2）[3β-O-（β-D-木糖基-（1→2）-β-D-葡萄糖基-（1→4）-[β-D-葡萄糖基-（1→2）]-α-L-阿拉伯糖基）-16α，28-二羟基-齐墩果-12-烯-30-酸30-O-β-D-葡萄糖酯]。结构鉴定基于光谱数据，包括二维核磁共振（相关光谱（COSY）、同核Hartmann-Hahn光谱（HOHAHA）、异核相关光谱（HETCOR）、异核多键相关（HMBC）和旋转框架NOE光谱（ROESY））实验以及一些化学反应。此外，已对分离出的皂苷及其前皂苷元和皂苷元进行了环磷酸腺苷磷酸二酯酶抑制活性评估，作为新药用化合物的初步筛选试验。
