Tachibana M, Abe S, Yoshimura H, Suzuki K, Matsuura H, Nagasue N, Nakamura T
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Dysphagia. 1995 Winter;10(1):49-52. doi: 10.1007/BF00261281.
Twelve patients (10.4%) had a history of partial gastrectomy among the 115 patients with squamous cell carcinoma of the esophagus. The clinical characteristics, nutritional parameters, and incidences of esophagitis of the resected specimens were investigated between 11 patients with esophageal carcinoma who had partial gastrectomy for peptic ulcer diseases (Group A) and 103 patients with esophageal carcinoma without any previous history of gastrectomy (Group B). Age, sex, tumor location, clinical stages, and cigarette and alcohol consumption were not different between the two groups. Hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin level in Group A were lower than those in Group B (p < 0.05). Serum zinc level in Group A was lower than that in Group B, but this difference was not significant. There was no difference in the incidences of esophagitis between the two groups. In conclusion, there is an association between partial gastrectomy and later development of squamous esophageal carcinoma. The role of malnutritional factors and gastroesophageal reflux, however, remain unclear. The long-term follow-up of patients after partial gastrectomy is warranted.
在115例食管鳞状细胞癌患者中，12例（10.4%）有部分胃切除术史。对11例因消化性溃疡疾病行部分胃切除术的食管癌患者（A组）和103例无胃切除术史的食管癌患者（B组）的切除标本的临床特征、营养参数和食管炎发生率进行了研究。两组患者的年龄、性别、肿瘤位置、临床分期以及吸烟和饮酒情况无差异。A组的血红蛋白、平均红细胞体积和平均红细胞血红蛋白水平低于B组（p<0.05）。A组血清锌水平低于B组，但差异无统计学意义。两组食管炎发生率无差异。总之，部分胃切除术与随后发生的食管鳞状细胞癌之间存在关联。然而，营养不良因素和胃食管反流的作用仍不清楚。对部分胃切除术后患者进行长期随访是必要的。
