Hirata Y, Uchigata Y
Tokyo Women's Medical School, Japan.
Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S153-7. doi: 10.1016/0168-8227(94)90243-7.
Since 1970, 197 patients with insulin autoimmune syndrome (IAS) showing severe spontaneous hypoglycemia have been reported in Japan. This is characterized by a high titer of anti-insulin autoantibodies without evidence of exogenous insulin administration. IAS is the third leading cause of spontaneous hypoglycemia in Japan, while only 21 cases have been reported in Europe and the United States. High levels of the extractable native human insulin and of the characteristic insulin autoantibodies in the sera of the IAS patients have been proved. Recently a significant association of HLA-DRB10406/DQA10301/DQB1*0302 with this syndrome has been found in the IAS patients in Japan.
自1970年以来，日本已报告197例患有胰岛素自身免疫综合征（IAS）且出现严重自发性低血糖的患者。其特征是抗胰岛素自身抗体滴度高，且无外源性胰岛素给药证据。IAS是日本自发性低血糖的第三大主要原因，而在欧洲和美国仅报告了21例。已证实IAS患者血清中可提取的天然人胰岛素和特征性胰岛素自身抗体水平较高。最近在日本的IAS患者中发现HLA - DRB10406/DQA10301/DQB1*0302与该综合征有显著关联。
