Sima A, Vlad A R, Timar B, Cotoi L, Sima L, Vlad M, Timar R
"Victor Babeș" University of Medicine and Pharmacy Timișoara, Diabetes, Nutrition and Metabolic Diseases, Department of Internal Medicine II, Timișoara, Romania.
Centre for Studies in Preventive Medicine, Timișoara, Romania.
Acta Endocrinol (Buchar). 2021 Apr-Jun;17(2):248-250. doi: 10.4183/aeb.2021.248.
A young Caucasian woman presents several episodes of severe fasting hypoglycemia. Fasting lab tests revealed: glycemia 28 mg/dL, insulinemia 143.3 µU/mL, insulin antibodies above 100 U/mL, leading to the diagnosis of insulin autoimmune syndrome. Due to lack of clinical improvement after 2 months, prednisone was started at 0.5 mg/kg/day, and then tapered by 5 mg every 5 days. Three weeks after discontinuing corticotherapy, the patient had no more severe fasting hypoglycemia, but occasionally postprandial mild hypoglycemia. Fasting lab tests showed: glycemia 83 mg/dL, insulinemia 58.6 µU/mL. At 5 hours during oral glucose tolerance test glycemia was 33 mg/dL, insulinemia 152.9 µU/mL.
一名年轻的白种女性出现多次严重的空腹低血糖发作。空腹实验室检查结果显示：血糖28mg/dL，胰岛素血症143.3µU/mL，胰岛素抗体高于100U/mL，从而诊断为胰岛素自身免疫综合征。由于2个月后临床症状未改善，开始使用泼尼松，剂量为0.5mg/kg/天，然后每5天减量5mg。停止皮质激素治疗3周后，患者不再出现严重的空腹低血糖，但偶尔会出现餐后轻度低血糖。空腹实验室检查显示：血糖83mg/dL，胰岛素血症58.6µU/mL。口服葡萄糖耐量试验5小时时血糖为33mg/dL，胰岛素血症152.9µU/mL。
