毛发和尿液分析：药物及其代谢物的相对分布

Hair and urine analysis: relative distribution of drugs and their metabolites.

作者信息

Bermejo Barrera A M, Strano Rossi S

机构信息

Department of Legal Medicine, University of Santiago de Compostela, Spain.

出版信息

Forensic Sci Int. 1995 Jan 5;70(1-3):203-10. doi: 10.1016/0379-0738(94)01614-b.

DOI:10.1016/0379-0738(94)01614-b

PMID:7860032

Abstract

This work studies the distribution of cocaine and heroin metabolites in hair and urine of living polidrug abusers. Cocaine, benzoylecgonine (BEG), ecgonine methyl ester (EME), morphine, codeine and 6-monoacetylmorphine (6-MAM) were simultaneously extracted and analyzed by GC/MS in SIM mode. The results obtained show a different distribution of heroin and cocaine metabolites in urine and hair. In urine, we generally find BEG and EME for cocaine abuse, and morphine for heroin abuse. In hair, we detect cocaine and MAM as major metabolites for cocaine and heroin abuse, respectively.

摘要

这项研究旨在探究同时滥用多种毒品的吸毒者毛发和尿液中可卡因及海洛因代谢物的分布情况。采用气相色谱-质谱联用仪（GC/MS）的选择离子监测（SIM）模式，同时提取并分析可卡因、苯甲酰爱康宁（BEG）、爱康宁甲酯（EME）、吗啡、可待因及6-单乙酰吗啡（6-MAM）。研究结果表明，海洛因和可卡因代谢物在尿液和毛发中的分布存在差异。尿液中，可卡因滥用者通常可检测到BEG和EME，海洛因滥用者则可检测到吗啡。毛发中，可卡因滥用的主要代谢物为可卡因，海洛因滥用的主要代谢物为6-MAM。