Melges F T
Am J Psychiatry. 1976 Sep;133(9):1024-8. doi: 10.1176/ajp.133.9.1024.
In a double-blind study using each subject as his own control, 6 normal subjects smoked 20 mg of THC within 10- and 45-minute periods ("fast" and "slow" conditions, respectively). Each subject also received placebo and doses of alcohol calculated to be as intoxicating as the THC doses. In fast conditions, THC induced greater difficulties with tracking information over time, greater disruptions of self-other interpersonal perceptions, and more persecutory ideation that did alcohol or placebo. Similar but less marked differences were found in the slow conditions. As hypothesized, changes in tracking difficulties, self-other metaperspectives, and persecutory ideation were substantially and significantly correlated.
在一项以每个受试者自身作为对照的双盲研究中，6名正常受试者分别在10分钟和45分钟内吸食20毫克四氢大麻酚（分别为“快速”和“慢速”条件）。每个受试者还接受了安慰剂以及计算得出的与四氢大麻酚剂量具有相同致醉效果的酒精剂量。在快速条件下，与酒精或安慰剂相比，四氢大麻酚随着时间推移在跟踪信息方面造成了更大困难，对自我与他人的人际感知产生了更大干扰，以及引发了更多被害妄想。在慢速条件下也发现了类似但不太明显的差异。正如所假设的那样，跟踪困难、自我与他人元视角以及被害妄想的变化之间存在实质性且显著的相关性。
