Fielding C J, Havel R J, Todd K M, Yeo K E, Schloetter M C, Weinberg V, Frost P H
Department of Physiology, University of California Medical Center, San Francisco 94143.
J Clin Invest. 1995 Feb;95(2):611-8. doi: 10.1172/JCI117705.
The individual effects of dietary cholesterol and fat saturation on plasma lipoprotein concentrations were determined in an ethnically diverse population of normolipidemic young men (52 Caucasian, 32 non-Caucasian). The experimental diets contained approximately 200 or 600 mg/d of cholesterol, 36-38% of calories as fat, and high or low proportions of saturated and polyunsaturated fat (polyunsaturated/saturated fat ratio approximately 0.8 vs 0.3). At the lower cholesterol intake, the high saturated fat diet had only a modest effect on LDL cholesterol in Caucasians (+ 6 mg/dl-1) and none in non-Caucasians. 600 mg cholesterol with high saturated fat led to a substantial mean increase in LDL cholesterol, which was significantly greater in Caucasian than in non-Caucasian subjects (+ 31 mg/dl vs 16 mg/dl, P < 0.005). 600 mg cholesterol with increased polyunsaturated fat gave a mean LDL increase of 16 mg/dl, lower than found when the same high cholesterol intake was coupled with increased saturated fat. Variation in cholesterol rather than the proportions of saturated and polyunsaturated fat had the most influence on LDL-cholesterol levels. Among non-Caucasians it was the only significant factor.
在血脂正常的年轻男性（52名白种人、32名非白种人）这一具有种族多样性的人群中，研究了膳食胆固醇和脂肪饱和度对血浆脂蛋白浓度的个体影响。实验饮食中胆固醇含量约为200或600毫克/天，脂肪提供的热量占36 - 38%，饱和脂肪和多不饱和脂肪的比例分别为高或低（多不饱和/饱和脂肪比例约为0.8对0.3）。在较低的胆固醇摄入量时，高饱和脂肪饮食对白种人的低密度脂蛋白胆固醇仅有适度影响（升高6毫克/分升），对非白种人则无影响。600毫克胆固醇与高饱和脂肪一起摄入会导致低密度脂蛋白胆固醇显著升高，白种人升高幅度显著高于非白种人（分别升高31毫克/分升和16毫克/分升，P < 0.005）。600毫克胆固醇与增加的多不饱和脂肪一起摄入时，低密度脂蛋白平均升高16毫克/分升，低于相同高胆固醇摄入量与增加的饱和脂肪一起摄入时的升高幅度。胆固醇的变化而非饱和脂肪和多不饱和脂肪的比例对低密度脂蛋白胆固醇水平影响最大。在非白种人中，这是唯一的显著因素。
