O'Regan S, Fong J S, de Chadarévian J P, Rishikof J R, Drummond K N
Ann Intern Med. 1976 Sep;85(3):325-7. doi: 10.7326/0003-4819-85-3-325.
Two patients, a 4-month-old infant girl with congenital syphilis and a 45-year-old man with secondary syphilis, had the nephrotic syndrome with glomerulonephritis. Immunoglobulins and treponemal antigenic material were seen in the glomeruli of both patients by immunofluorescence microscopic studies of renal tissue. Electron micrographs showed subepithelial electron dense deposits along the glomerular basement membrane. This confirms earlier suggestions that the renal injury is of an immune-complex type.
两名患者，一名患有先天性梅毒的4个月大女婴和一名患有二期梅毒的45岁男性，患有伴有肾小球肾炎的肾病综合征。通过对肾组织的免疫荧光显微镜研究，在两名患者的肾小球中均可见免疫球蛋白和梅毒螺旋体抗原物质。电子显微镜照片显示沿肾小球基底膜有上皮下电子致密沉积物。这证实了早期的推测，即肾损伤属于免疫复合物类型。
