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梅毒螺旋体抗原在梅毒性肾小球肾炎免疫发病机制中的作用

Treponemal antigen in immunopathogenesis of syphilitic glomerulonephritis.

作者信息

Tourville D R, Byrd L H, Kim D U, Zajd D, Lee I, Reichman L B, Baskin S

出版信息

Am J Pathol. 1976 Mar;82(3):479-92.

PMID:130804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032412/
Abstract

A patient with syphilitic glomerulonephritis had a renal biopsy and was treated for secondary syphilis. Light, electron, and immunofluorescence microscopic studies revealed an acute proliferative glomerulonephritis with subepithelial, intramembranous, and subendothelial immune complex deposits containing IgG, IgA, IgM, C4, and C3. Similar local deposits containing predominantly IgM were noted in areas of mesangial proliferation. Indirect fluorescent antibody studies employing rabbit treponemal antibody and sheep antirabbit globulin conjugate revealed the presence of treponemal antigen in the glomerular deposits. This finding provides strong evidence for the immunopathogenesis of the glomerular lesion as well as a causal link with Treponema pallidum.

摘要

一名患有梅毒肾小球肾炎的患者接受了肾活检，并接受了二期梅毒治疗。光镜、电镜和免疫荧光显微镜研究显示为急性增殖性肾小球肾炎，伴有上皮下、膜内和内皮下免疫复合物沉积，其中含有IgG、IgA、IgM、C4和C3。在系膜增生区域也发现了主要含IgM的类似局部沉积物。采用兔梅毒螺旋体抗体和羊抗兔球蛋白结合物的间接荧光抗体研究显示，肾小球沉积物中存在梅毒螺旋体抗原。这一发现为肾小球病变的免疫发病机制以及与梅毒螺旋体的因果关系提供了有力证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/d88fec4c8ccb/amjpathol00454-0058-d.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/5b05d9493677/amjpathol00454-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/6fdaea3ea8c6/amjpathol00454-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/e75efb6671a9/amjpathol00454-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/8619fc9e8364/amjpathol00454-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/6da150f8b550/amjpathol00454-0057-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/a8a53460339a/amjpathol00454-0057-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/5d0f3d559b9a/amjpathol00454-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/51977b194091/amjpathol00454-0058-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/97a1917d42d5/amjpathol00454-0058-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb5c/2032412/d88fec4c8ccb/amjpathol00454-0058-d.jpg

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本文引用的文献

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J Exp Med. 1950 Jan 1;91(1):1-13. doi: 10.1084/jem.91.1.1.
2
The nephrotic syndrome in secondary syphilis: report of a case with renal biopsy findings.二期梅毒所致肾病综合征：一例肾活检结果报告
Ann Intern Med. 1965 Dec;63(6):1047-58. doi: 10.7326/0003-4819-63-6-1047.
3
Electron microscopic studies of human glomerulonephritis with ferritin-conjugated antibody. Localization of antigen-antibody complexes in glomerular structures of patients with acute glomerulonephritis.
CEN Case Rep. 2024 Apr;13(2):86-92. doi: 10.1007/s13730-023-00803-9. Epub 2023 Jun 23.
4
How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy.时代变了！膜性肾病的抗原宝库。
Front Immunol. 2021 Nov 26;12:800242. doi: 10.3389/fimmu.2021.800242. eCollection 2021.
5
Syphilis-related rapidly progressive glomerulonephritis: a case presentation.梅毒相关性快速进展性肾小球肾炎：病例报告。
BMC Nephrol. 2021 May 25;22(1):196. doi: 10.1186/s12882-021-02404-z.
6
Syphilis-Associated Acute Renal Failure and Hepatitis in the Setting of Human Immunodeficiency Virus Coinfection.梅毒相关性急性肾功能衰竭和乙型肝炎在人类免疫缺陷病毒合并感染的情况下。
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Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.一名青少年孕妇中与梅毒感染相关的急性IgA主导型肾小球肾炎：一种新的疾病关联
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5
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