Lansdown A B, Payne M J
Department of Comparative Biology, Charing Cross and Westminster Medical School, London, UK.
J R Coll Surg Edinb. 1994 Oct;39(5):284-8.
Kaltostat swabs were implanted subcutaneously in rats to evaluate their biodegradability and ability to evoke local tissue reactions. Implant sites were evaluated after 24 h and after 7 days, 28 days and 12 weeks. Histological sections showed no noticeable degradation of the Kaltostat within the 3 month observation period, contrary to some published reports. Following subsidence of a modest foreign body reaction, implants became embedded in thin fibrous sheaths which were infiltrated with vascular channels and fibroblasts. This study demonstrates that Kaltostat fibres are well tolerated following subcutaneous implantation in the rat model and present no obvious toxic risk or contraindication to their use as wound dressings or as haemostatic agents in general surgery.
将卡尔托斯塔特拭子皮下植入大鼠体内，以评估其生物降解性和引发局部组织反应的能力。分别在24小时后以及7天、28天和12周后对植入部位进行评估。组织学切片显示，在3个月的观察期内，卡尔托斯塔特没有明显降解，这与一些已发表的报告相反。在适度的异物反应消退后，植入物被包埋在薄的纤维鞘中，纤维鞘中有血管通道和成纤维细胞浸润。这项研究表明，在大鼠模型中皮下植入后，卡尔托斯塔特纤维耐受性良好，作为伤口敷料或普通外科止血剂使用时，没有明显的毒性风险或禁忌证。
