Khan S R, Glenton P A
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610-0275.
J Urol. 1995 Mar;153(3 Pt 1):811-7.
Calcium phosphate (CaP) and calcium oxalate (CaOx) are the two most common crystalline constituents of human urinary stones. Calcium phosphate is often recognized as the nucleator of CaOx crystals, but the relationship between the two is not yet clearly understood. Using rat models of nephrolithiasis, we studied the role of CaP in renal deposition of CaOx. Calcium oxalate nephrolithiasis was brought about by inducing hyperoxaluria, while CaP CaOx nephrolithiasis was produced by dietary manipulation. Under similar urinary CaOx or CaP supersaturations, male rats were prone to form CaOx deposits while female rats were susceptible to produce CaP deposits in their kidneys. Crystal deposition in females was generally localized to the corticomedullary junction and in males to the renal papillae. The results indicate that gender plays an important role in the type and location of crystal deposition in the kidneys. In addition, deposition of CaP does not appear to influence the deposition of CaOx.
磷酸钙（CaP）和草酸钙（CaOx）是人类尿结石中两种最常见的晶体成分。磷酸钙常被认为是草酸钙晶体的成核剂，但二者之间的关系尚未完全明晰。我们利用肾结石大鼠模型，研究了磷酸钙在草酸钙肾沉积中的作用。通过诱导高草酸尿症引发草酸钙肾结石，而通过饮食控制产生磷酸钙 - 草酸钙肾结石。在相似的尿草酸钙或磷酸钙过饱和度条件下，雄性大鼠易于形成草酸钙沉积物，而雌性大鼠的肾脏则易产生磷酸钙沉积物。雌性大鼠的晶体沉积通常定位于皮质髓质交界处，而雄性大鼠则定位于肾乳头。结果表明，性别在肾脏晶体沉积的类型和位置方面起着重要作用。此外，磷酸钙的沉积似乎并不影响草酸钙的沉积。
