Healy D J, Meador-Woodruff J H
Department of Psychiatry, Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0720.
Neuropeptides. 1994 Nov;27(5):277-84. doi: 10.1016/0143-4179(94)90108-2.
The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The concentrations of all four peptides were significantly greater in the striatum compared to the cortex. In general, concentrations of each peptide tended to be higher in allocortex than in neocortex. Possible inter- and intradomain processing differences, as estimated by ratios of these peptides, did not vary within cortex, but the intradomain peptide ratio, dyn A (1-17)/dyn A (1-8), was significantly greater in cortex than in striatum. These results indicate that prodynorphin is, in some ways, uniquely processed in the primate. Particularly unusual is the relatively low abundance of prodynorphin-derived products in the cortex, in the face of moderately high levels of kappa opiate receptor expression.
在东半球猴（食蟹猴）的10个皮质区域和纹状体中，测定了四种前强啡肽衍生肽（强啡肽A (1 - 17)、强啡肽A (1 - 8)、强啡肽B和α-新内啡肽）的分布。α-新内啡肽是皮质和纹状体中含量最丰富的肽。与皮质相比，纹状体中所有四种肽的浓度均显著更高。一般来说，各肽在旧皮质中的浓度往往高于新皮质。根据这些肽的比例估算，可能存在的区域间和区域内加工差异在皮质内并无变化，但皮质内的肽比例（强啡肽A (1 - 17)/强啡肽A (1 - 8)）在皮质中显著高于纹状体。这些结果表明，前强啡肽在某些方面在灵长类动物中存在独特的加工方式。特别不寻常的是，尽管κ阿片受体表达水平适中，但皮质中前强啡肽衍生产物的丰度相对较低。
