Ramsdell C D, Meador-Woodruff J H
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0720.
Neuropeptides. 1993 Aug;25(2):131-8. doi: 10.1016/0143-4179(93)90093-p.
The distributions and extent of processing of four prodynorphin-derived peptides (dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neoendorphin) were determined in ten regions of the cortex as well as in the striatum of the guinea-pig. There were significant differences between concentrations of these peptides in most cortical regions, with alpha-neoendorphin being several times more abundant than the other peptides, and dynorphin A (1-17) being present in the least amount. There were significant between-region differences in concentration for each peptide, although most regions had concentrations similar to those seen in the striatum. Concentrations of each peptide tended to be higher in piriform, entorhinal, motor, and auditory cortex than in other cortical regions. The extent of processing of prodynorphin varied across cortical regions as well, primarily due to the extent of processing to alpha-neoendorphin. Prodynorphin mRNA levels were not significantly different between cortical regions or from the amount observed in the striatum. Although specific regional variation exists, it appears that in general prodynorphin is expressed and processed in a similar manner in the cortex as in the striatum.
在豚鼠的皮质十个区域以及纹状体中，测定了四种强啡肽原衍生肽（强啡肽A（1 - 17）、强啡肽A（1 - 8）、强啡肽B和α-新内啡肽）的分布及加工程度。这些肽在大多数皮质区域的浓度存在显著差异，α-新内啡肽的丰度比其他肽高几倍，而强啡肽A（1 - 17）的含量最少。每种肽在不同区域的浓度也存在显著差异，尽管大多数区域的浓度与纹状体中的相似。梨状皮质、内嗅皮质、运动皮质和听觉皮质中每种肽的浓度往往高于其他皮质区域。强啡肽原的加工程度在不同皮质区域也有所不同，主要是由于加工成α-新内啡肽的程度不同。强啡肽原mRNA水平在不同皮质区域之间或与纹状体中观察到的量没有显著差异。尽管存在特定的区域差异，但总体上强啡肽原在皮质中的表达和加工方式似乎与纹状体中相似。
