Paige S R, Fitzpatrick D F, Kline J P, Balogh S E, Hendricks S E
Creighton-Nebraska Department of Psychiatry, University of Nebraska at Omaha.
Neuropsychobiology. 1994;30(4):197-201. doi: 10.1159/000119161.
We measured event-related potential (ERP) component amplitudes to four intensities of randomly presented tones. Patients diagnosed with major depressive disorder were tested prior to and following a clinical trial of antidepressant medication. Slope of P2 amplitude as a function of stimulus intensity was calculated for each subject and condition. Subjects were divided into two groups (responders and nonresponders) based on their Hamilton Rating Scale for depression scores following treatment. Responders had significantly larger P2 slopes prior to treatment than did nonresponders. P2 slopes did not differ significantly between responders and nonresponders following antidepressant treatment. These data support the conclusion that P2 amplitude/intensity slope may be a predictor of response to treatment with antidepressant medication.
我们测量了与事件相关电位（ERP）成分对四种随机呈现音调强度的反应。对被诊断为重度抑郁症的患者在进行抗抑郁药物临床试验之前和之后进行了测试。为每个受试者和每种情况计算了P2波幅随刺激强度变化的斜率。根据治疗后他们的汉密尔顿抑郁量表评分，将受试者分为两组（反应者和无反应者）。治疗前，反应者的P2斜率显著大于无反应者。抗抑郁治疗后，反应者和无反应者的P2斜率无显著差异。这些数据支持以下结论：P2波幅/强度斜率可能是抗抑郁药物治疗反应的一个预测指标。
