Opatowsky I, Feldman R M, Gross R, Feldman S T
Department of Ophthalmology, University of California, San Diego School of Medicine, La Jolla.
Ophthalmology. 1995 Feb;102(2):177-9. doi: 10.1016/s0161-6420(95)31039-1.
The ocular hypertensive response to corticosteroids is well established. Elevated intraocular pressure (IOP) secondary to corticosteroids by nasal spray or inhalation has rarely been reported.
Three patients showed a possible ocular hypertensive response to beclomethasone dipropionate by nasal spray or inhalation. In two patients, the IOP returned to pretreatment levels after discontinuing nasal corticosteroid spray. One patient required medication to control IOP with continued inhaled corticosteroid. One patient later demonstrated an ocular hypertensive response to oral steroids.
Corticosteroids by nasal spray or inhalation may cause ocular hypertension in susceptible patients. The authors recommend surveillance of IOP in patients using these medications.
皮质类固醇引起的眼压升高反应已得到充分证实。经鼻喷雾或吸入皮质类固醇继发的眼压升高（IOP）鲜有报道。
三名患者经鼻喷雾或吸入二丙酸倍氯米松后出现可能的眼压升高反应。两名患者在停用鼻用皮质类固醇喷雾剂后眼压恢复到治疗前水平。一名患者在持续吸入皮质类固醇的情况下需要药物控制眼压。一名患者后来对口服类固醇表现出眼压升高反应。
经鼻喷雾或吸入皮质类固醇可能会使易感患者发生眼压升高。作者建议对使用这些药物的患者监测眼压。
