Oztürk F, Yücetürk A V, Kurt E, Unlü H H, Ilker S S
Department of Ophthalmology, Celal Bayar University Medical Faculty, Manisa, Turkey.
Ear Nose Throat J. 1998 Oct;77(10):846-8, 850-1.
It is possible that corticosteroids administered via nasal spray might reach ocular structures in levels sufficient to provoke an ocular hypertensive response and cause posterior subcapsular cataracts (PSCs) in susceptible individuals. In the present study, 26 patients who had undergone endoscopic sinus surgery were evaluated prospectively with respect to intraocular pressure and PSC formation following the use of nasal steroids for at least three months. Eighteen patients (69%) self-administered 200 micrograms/day of budesonide nasal spray twice daily, and eight patients (31%) self-administered 200 micrograms/day of beclomethasone dipropionate nasal spray twice daily, for a period of three to 19 months (mean 8.8 +/- 3.6 months). Ophthalmologic examination, tonometry, visual field testing and biomicroscopic studies revealed no evidence of ocular hypertension or PSCs during postoperative follow-up. We conclude that intranasal corticosteroids can be used safely for prolonged periods without increasing the risk of ocular hypertension or PSCs.
通过鼻喷雾剂给药的皮质类固醇可能会以足以引发眼内高压反应的水平到达眼部结构，并在易感个体中导致后囊下白内障（PSC）。在本研究中，对26例接受内镜鼻窦手术的患者进行了前瞻性评估，观察其在使用鼻用类固醇至少三个月后的眼压和PSC形成情况。18例患者（69%）每天自行使用200微克布地奈德鼻喷雾剂，每日两次，8例患者（31%）每天自行使用200微克丙酸倍氯米松鼻喷雾剂，每日两次，持续三至19个月（平均8.8±3.6个月）。眼科检查、眼压测量、视野测试和生物显微镜研究显示，术后随访期间没有眼内高压或PSC的证据。我们得出结论，鼻内皮质类固醇可以长期安全使用，而不会增加眼内高压或PSC的风险。
