Vingerling J R, Dielemans I, Hofman A, Grobbee D E, Hijmering M, Kramer C F, de Jong P T
Department of Ophthalmology, Erasmus University Medical School, Rotterdam, The Netherlands.
Ophthalmology. 1995 Feb;102(2):205-10. doi: 10.1016/s0161-6420(95)31034-2.
To determine the prevalence of age-related maculopathy in an elderly population in The Netherlands.
Fundus photographs of 6251 participants of the Rotterdam Study, a single-center prospective follow-up study in persons 55 to 98 years of age, were reviewed for the presence of drusen, pigmentary abnormalities, and atrophic or neovascular age-related macular degeneration.
The prevalence of at least one drusen of 63 microns or larger increased from 40.8% in persons 55 to 64 years of age to 52.6% in those 85 years of age or older. Similarly, the prevalence of the following abnormalities increased significantly in these age categories: drusen of 125 microns or larger from 4.8% to 17.5%, retinal pigment epithelial hypopigmentations from 3.5% to 9.0%, and increased retinal pigment from 3.7% to 15.3%. Atrophic or neovascular age-related macular degeneration was present in 1.7% of the total population. Atrophic age-related macular degeneration increased from 0.1% in persons 55 to 64 years of age to 3.7% in those 85 years of age or older. Neovascular age-related macular degeneration increased from 0.1% to 7.4% in these age groups. No sex differences were observed for these lesions.
The prevalence of atrophic or neovascular age-related macular degeneration is 1.7%. In those 55 years of age or older, the prevalence increases strongly with age and it is similar in men and women. Neovascular age-related macular degeneration was twice as common as atrophic age-related macular degeneration. These findings suggest that age-related maculopathy may be less common in this European population than in similar populations in the United States.
确定荷兰老年人群中年龄相关性黄斑病变的患病率。
对鹿特丹研究中6251名参与者的眼底照片进行了回顾，该研究是一项针对55至98岁人群的单中心前瞻性随访研究，以检查是否存在玻璃膜疣、色素异常以及萎缩性或新生血管性年龄相关性黄斑变性。
至少一个直径63微米或更大的玻璃膜疣的患病率从55至64岁人群中的40.8%增加到85岁及以上人群中的52.6%。同样，在这些年龄组中，以下异常的患病率显著增加：直径125微米或更大的玻璃膜疣从4.8%增加到17.5%，视网膜色素上皮色素减退从3.5%增加到9.0%，视网膜色素增加从3.7%增加到15.3%。萎缩性或新生血管性年龄相关性黄斑变性在总人口中的患病率为1.7%。萎缩性年龄相关性黄斑变性从55至64岁人群中的0.1%增加到85岁及以上人群中的3.7%。新生血管性年龄相关性黄斑变性在这些年龄组中从0.1%增加到7.4%。未观察到这些病变存在性别差异。
萎缩性或新生血管性年龄相关性黄斑变性的患病率为1.7%。在55岁及以上人群中，患病率随年龄显著增加，且男性和女性相似。新生血管性年龄相关性黄斑变性的患病率是萎缩性年龄相关性黄斑变性的两倍。这些发现表明，与美国类似人群相比，年龄相关性黄斑病变在该欧洲人群中可能不太常见。
