年龄相关性黄斑病变的患病率。比弗迪姆眼研究。

Prevalence of age-related maculopathy. The Beaver Dam Eye Study.

作者信息

Klein R, Klein B E, Linton K L

机构信息

Department of Ophthalmology, University of Wisconsin, Madison 53792.

出版信息

Ophthalmology. 1992 Jun;99(6):933-43. doi: 10.1016/s0161-6420(92)31871-8.

DOI:10.1016/s0161-6420(92)31871-8

PMID:1630784

Abstract

PURPOSE

The relationships of retinal drusen, retinal pigmentary abnormalities, and macular degeneration to age and sex were studied in 4926 people between the ages of 43 and 86 years who participated in the Beaver Dam Eye Study.

METHODS

The presence and severity of various characteristics of drusen and other lesions typical of age-related maculopathy were determined by grading stereoscopic color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System.

RESULTS

One or more drusen were present in the macular area of at least 1 eye in 95.5% of the population. People 75 years of age or older had significantly higher frequencies (P less than 0.01) of the following characteristics than people 43 to 54 years of age: larger sized drusen (greater than or equal to 125 microns, 24.0% versus 1.9%), soft indistinct drusen (23.0% versus 2.1%), retinal pigment abnormalities (26.6% versus 7.3%), exudative macular degeneration (5.2% versus 0.1%), and geographic atrophy (2.0% versus 0%).

CONCLUSION

These data indicate signs of age-related maculopathy are common in people 75 years of age or older and may pose a substantial public health problem.

摘要

目的

在4926名年龄在43至86岁之间参与比弗迪尔姆眼研究的人群中，研究视网膜玻璃膜疣、视网膜色素异常和黄斑变性与年龄及性别的关系。

方法

采用威斯康星年龄相关性黄斑病变分级系统，通过对立体彩色眼底照片进行分级，确定玻璃膜疣及其他年龄相关性黄斑病变典型特征的存在情况和严重程度。

结果

95.5%的人群至少一只眼睛的黄斑区存在一个或多个玻璃膜疣。75岁及以上人群以下特征的出现频率显著高于43至54岁人群（P<0.01）：较大尺寸的玻璃膜疣（大于或等于125微米，24.0%对1.9%）、软性边界不清的玻璃膜疣（23.0%对2.1%）、视网膜色素异常（26.6%对7.3%）、渗出性黄斑变性（5.2%对0.1%）和地图样萎缩（2.0%对0%）。