非狼疮患者中的抗Ro/SS-A抗体阳性间质性肺炎

Anti-Ro/SS-A antibody-positive interstitial pneumonitis in a non-lupus patient.

作者信息

Inoue T, Okamura M, Negoro N, Konishi Y, Nishimura M, Umetani N, Takeda T, Inoue K, Kanayama Y

机构信息

First Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

Osaka City Med J. 1994 Dec;40(2):117-20.

PMID:7862426

Abstract

We describe a 42-year-old anti-Ro/SS-A antibody positive non-lupus patient who developed interstitial pneumonitis in combination with several common clinical features with previously reported lupus pneumonitis patients whose anti-Ro/SS-A antibodies were positive, while whose antinuclear antibodies were negative. We consider that these patients may belong to a same new clinical entity. A variety of characteristic manifestations related to anti-Ro/SS-A antibodies has been reported in patients with systemic lupus erythematosus (SLE) and other connective tissue diseases [1] [2], and an association between these antibodies with pulmonary parenchymal involvement has been reported by Hedgpeth and Boulware in patients with SLE [3] [4]. We report here a 42-year-old non-lupus male patient with pulmonary fibrosis who presented with anti-Ro/SS-A antibodies.

摘要

我们描述了一名42岁的抗Ro/SS-A抗体阳性的非狼疮患者，该患者出现了间质性肺炎，并伴有一些与先前报道的抗Ro/SS-A抗体阳性、抗核抗体阴性的狼疮肺炎患者相同的常见临床特征。我们认为这些患者可能属于同一新的临床实体。系统性红斑狼疮（SLE）和其他结缔组织病患者中已报道了与抗Ro/SS-A抗体相关的多种特征性表现[1][2]，Hedgpeth和Boulware在SLE患者中报道了这些抗体与肺实质受累之间的关联[3][4]。我们在此报告一名42岁患有肺纤维化的非狼疮男性患者，其抗Ro/SS-A抗体呈阳性。