Czarkowski M, Chojnowski K, Osikowska-Loksztejn M, Chodakowska J
Kliniki Nadciśnienia Tetniczego i Chorób Naczyń AM w Warszawie.
Kardiol Pol. 1993 Jun;38(6):412-6.
Serum adrenaline (AD) and noradrenaline (NA) were measured by RIA method in two groups of young males: group S (n = 54) with positive family history of essential hypertension (EH) and group K (n = 9) with negative family history of EH (mean age: 24.6 +/- 3.3 i 23.6 +/- 3.6 years respectively). AD and NA concentrations were estimated in basic conditions (AD1, NA1) and after 10 min of passive vertical posture(AD2, NA2). In group S AD1 concentration was higher than in group K (54.4 +/- 24.4 i 37.8 +/- 15.6 pg/ml respectively, p < 0.05). In group S a positive correlation was found between mean systolic blood pressure (SBP) and mean heart rate (HR) estimated during 5-hours monitoring by Spacelab IGR 5300 ambulatory blood pressure and heart rate monitoring system (r = 0.5, p < or = 0.01). Pearson's correlation coefficient (Pcc). In this same group positive correlations were also found between AD2 and SBP - r = 0.31, p < 0.05 (Pcc) and between AD2 and HR: r = 0.33, p < 0.05 (Pcc). Results of 5-hours blood pressure monitoring showed that 15 of 54 males from group S had SBP > 139 mmHg (group S1). In group S1, AD1 and AD2 concentrations were higher than in group K (AD1: 366 +/- 144; 206 +/- 85, p < 0.01 and AD2: 626 +/- 266; 369 +/- 156 fmol/ml, p < 0.05 respectively). No differences were found in AD1, AD2, NA1 and NA2 concentration between group K and normotensive (SBB < 140 mmHg) males with positive family history of EH: group S2. In young males with positive family history of EH, the elevation of blood pressure might be caused by an augmented activity of the adrenal medulla.
采用放射免疫分析法（RIA）对两组年轻男性的血清肾上腺素（AD）和去甲肾上腺素（NA）进行了测定：S组（n = 54）有原发性高血压（EH）家族史阳性，K组（n = 9）有EH家族史阴性（平均年龄分别为：24.6±3.3岁和23.6±3.6岁）。在基础状态下（AD1、NA1）以及被动垂直体位10分钟后（AD2、NA2）对AD和NA浓度进行了评估。S组的AD1浓度高于K组（分别为54.4±24.4和37.8±15.6 pg/ml，p<0.05）。在S组中，通过太空实验室IGR 5300动态血压和心率监测系统进行5小时监测期间，平均收缩压（SBP）与平均心率（HR）之间存在正相关（r = 0.5，p≤0.01），为皮尔逊相关系数（Pcc）。在同一组中，AD2与SBP之间也存在正相关：r = 0.31，p<0.05（Pcc），AD2与HR之间也存在正相关：r = 0.33，p<0.05（Pcc）。5小时血压监测结果显示，S组54名男性中有15人的SBP>139 mmHg（S1组）。在S1组中，AD1和AD2浓度高于K组（AD1：366±144；206±85，p<0.01；AD2：626±266；369±156 fmol/ml，p<0.05）。K组与有EH家族史阳性的血压正常（SBB<140 mmHg）男性（S2组）之间，在AD1、AD2、NA1和NA2浓度方面未发现差异。在有EH家族史阳性的年轻男性中，血压升高可能是由肾上腺髓质活性增强引起的。
