Musialik D, Raszeja-Wanic B, Głuszek J, Pieczyńska A
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM, Poznaniu.
Pol Tyg Lek. 1994;49(10-11):239-41.
The study aimed at evaluating an excretion of beta 2-microglobulin with the urine of hypertensive patients. Thirty patients with mild-to-moderate hypertension (diastolic blood pressure 14.26 +/- 0.86 kPa) and 13 patients with severe hypertension (diastolic blood pressure 17.8 +/- 1.7 kPa) were included into the studies. Significantly increased beta 2-microglobulin excretion with the urine was noted in both groups with the highest values in patients with severe blood hypertension. Moreover, significant correlation between tubular reabsorption of beta 2-microglobulin and diastolic blood pressure was noted in both groups. Increased excretion of beta 2-microglobulin in the arterial hypertension may be due to an increased glomerular filtration of this protein and/or decreased reabsorption in proximal tubule.
该研究旨在评估高血压患者尿液中β2-微球蛋白的排泄情况。30例轻度至中度高血压患者（舒张压14.26±0.86kPa）和13例重度高血压患者（舒张压17.8±1.7kPa）被纳入研究。两组患者尿液中β2-微球蛋白排泄均显著增加，重度高血压患者的值最高。此外，两组患者β2-微球蛋白的肾小管重吸收与舒张压之间均存在显著相关性。动脉高血压中β2-微球蛋白排泄增加可能是由于该蛋白肾小球滤过增加和/或近端小管重吸收减少所致。
