Rosenwasser A M, Hayes M J
Department of Psychology, University of Maine, Orono 04469.
Psychopharmacology (Berl). 1994 Jun;115(1-2):237-44. doi: 10.1007/BF02244777.
Neonatal treatment with monoamine reuptake inhibitors results in a constellation of neurobehavioral alterations in adult rats that may model human depression. Since alterations in circadian rhythmicity have been reported in both depressed patients and in animal depression models, the present study examined the effects of neonatal desipramine treatment (5.0 mg/kg SC from postnatal day 7 through 22) on free-running circadian drinking rhythms. Rhythmicity was examined in constant darkness (DD), constant light (LL), and during adult desipramine treatment (0.25 mg/ml via the drinking water). Compared with saline-treated controls, neonatal desipramine lengthened free-running period in DD, blunted the period-altering effect of LL, and potentiated the period-altering effect of adult desipramine treatment. Neonatal desipramine treatment also increased circadian amplitude and spectral magnitude, but did not modify the effects of light or adult desipramine on these parameters. These results provide further evidence that behavioral depression is associated with alterations in circadian rhythmicity, and are consistent with the hypothesis that such relationships are mediated by brain monoaminergic systems.
用单胺再摄取抑制剂对新生大鼠进行治疗会导致成年大鼠出现一系列神经行为改变，这些改变可能可作为人类抑郁症的模型。由于在抑郁症患者和动物抑郁症模型中均已报道了昼夜节律的改变，因此本研究考察了新生大鼠经去甲丙咪嗪治疗（从出生后第7天至22天，皮下注射5.0mg/kg）对自由活动的昼夜饮水节律的影响。在持续黑暗（DD）、持续光照（LL）以及成年大鼠经去甲丙咪嗪治疗（通过饮用水给予0.25mg/ml）期间对节律性进行了考察。与用生理盐水处理的对照组相比，新生大鼠经去甲丙咪嗪治疗后在DD条件下自由活动周期延长，减弱了LL对周期的改变作用，并增强了成年大鼠经去甲丙咪嗪治疗对周期的改变作用。新生大鼠经去甲丙咪嗪治疗还增加了昼夜节律的振幅和频谱幅度，但并未改变光照或成年大鼠经去甲丙咪嗪治疗对这些参数的影响。这些结果进一步证明行为性抑郁与昼夜节律的改变有关，并且与这样一种假说相符，即这种关系是由脑单胺能系统介导的。
