Rosenwasser A M, Plante L
Department of Psychology, University of Maine, Orono 04469.
Physiol Behav. 1993 Jan;53(1):23-9. doi: 10.1016/0031-9384(93)90006-2.
The spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) inbred rat strains have been subjected to extensive behavioral and neurochemical characterization. The present study examined free-running circadian activity rhythms in these two strains. Because previous studies indicated that free-running rhythms are altered during chronic clonidine administration, and that SHRs and WKYs may respond differentially to clonidine, the effects of this agent on rhythmicity were compared in the two strains. SHRs were hyperactive and showed shorter free-running periods than did WKYs. Clonidine administration altered free-running rhythms similarly in the two strains, but reduced activity levels only in the relatively hyperactive SHRs. These results are consistent with the hypothesis that central noradrenergic systems influence circadian locomotor activity rhythms.
自发性高血压（SHR）和血压正常的京都Wistar（WKY）近交系大鼠已经接受了广泛的行为和神经化学特征分析。本研究检测了这两个品系的自由活动昼夜节律。因为先前的研究表明，在长期给予可乐定期间自由活动节律会发生改变，并且SHR和WKY对可乐定的反应可能不同，所以比较了该药物在这两个品系中对节律性的影响。SHR比WKY活动亢进，且自由活动周期更短。给予可乐定后，两个品系的自由活动节律改变相似，但仅使相对活动亢进的SHR的活动水平降低。这些结果与中枢去甲肾上腺素能系统影响昼夜运动活动节律的假说一致。
