Baerheim A, Larsen E, Digranes A
Department of Public Health and Primary Health Care, University of Bergen, Norway.
Scand J Prim Health Care. 1994 Dec;12(4):239-43. doi: 10.3109/02813439409029247.
To examine whether vaginal application of Lactobacillus casei v. rhamnosus reduces the reinfection rate in cystitis-prone women.
A controlled, randomized, double-blind clinical trial.
Division for General Practice, University of Bergen, Norway.
Vaginal application of lactobacilli twice weekly.
47 women, aged 18-50 years, reporting three or more episodes of distal urinary symptoms during the previous 12 months, of which at least one episode had been medically verified as a lower UTI.
The incidence rate of lower UTI during 6 months' follow-up.
No difference in infection rate between the two groups; the incidence rate ratio between the treatment group and the placebo group was 1.41 (95% confidence interval 0.88-1.98). Lactobacilli were not found more frequently periurethrally in the treatment group than in the control group.
It is still uncertain whether vaginal application of lactobacilli reduces the infection rate in cystitis-prone women.
研究阴道应用干酪乳杆菌鼠李糖亚种是否能降低易患膀胱炎女性的再感染率。
一项对照、随机、双盲临床试验。
挪威卑尔根大学全科医学科。
每周两次阴道应用乳酸菌。
47名年龄在18至50岁之间的女性，她们在过去12个月内报告有三次或更多次远端尿路症状发作，其中至少有一次经医学证实为下尿路感染。
6个月随访期间下尿路感染的发病率。
两组感染率无差异；治疗组与安慰剂组的发病率比为1.41（95%置信区间0.88 - 1.98）。治疗组尿道周围发现乳酸菌的频率并不高于对照组。
阴道应用乳酸菌是否能降低易患膀胱炎女性的感染率仍不确定。
