Fleischhauer J
Arzneimittelforschung. 1976;26(6):1183-4.
53 patients with a neuroleptic-induced parkinson syndrome were suddenly withdrawn from their antiparkinson medication without changes in neuroleptic medication. All but 10 patients had been given antiparkinson drugs for more than 1 year. Slight and constant deterioration in their condition occurred in 4 female patients within 1-3 weeks following withdrawal. The neuroleptic dose was increased in 7 patients, a slight transient deterioration of the parkinson symptoms occurring in 2 cases. Investigation into the longitudinal course of the disease revealed that the intensity of symptoms is not always steady, but that certain variations occur. Our results confirm similar available studies in that the incidence of relapses in cases of neuroleptically conditioned Parkinson's disease is very low in patients with anti-parkinson medication for long period; this incidence of relapses amounts to 8% in our study.
53例患有抗精神病药物所致帕金森综合征的患者突然停用抗帕金森药物，而抗精神病药物剂量不变。除10例患者外，其余患者服用抗帕金森药物均超过1年。停药后1 - 3周内，4例女性患者病情出现轻微且持续恶化。7例患者增加了抗精神病药物剂量，其中2例帕金森症状出现轻微短暂恶化。对该疾病纵向病程的调查显示，症状强度并非始终稳定，而是会出现一定变化。我们的结果证实了现有类似研究，即长期服用抗帕金森药物的抗精神病药物所致帕金森病患者复发率很低；在我们的研究中，这一复发率为8%。
