Yoshida A, Morozumi K, Takeda A, Koyama K
Division of Nephrology, Nagoya Daini Red Cross Hospital.
Ryumachi. 1994 Dec;34(6):976-80.
The first report of mixed connective tissue disease (MCTD) was described that nephropathy was rare complication of the patients with MCTD. Recently, some authors reported that the nephropathy was 25-50% of patients with MCTD. This report investigated the histopathological findings of patients with MCTD. This study was conducted on 17 patients associated with MCTD. In clinical features, there were six of nephrotic syndrome and two of hematuria and proteinuria. They were normal renal function, expect for one case (case MF). In pathological findings, there were four of membranous nephropathy, two of mesangial proliferative glomerulonephritis, including one of IgA nephropathy, and 11 of minor glomerular abnormality. Three cases translated to systemic lupus erythematosus (SLE) during follow-up period (1 to 5 years). They had hypocomplementemia and membranous nephropathy in common. In conclusion, the nephropathy is not rare complication in patients with MCTD. Sex of the 17 patients (35.3%) with MCTD have nephropathy. MCTD cases with immune-complex glomerulonephritis are likely to transit from MCTD to SLE.
混合性结缔组织病（MCTD）的首份报告称，肾病是MCTD患者罕见的并发症。最近，一些作者报告称，MCTD患者中肾病的发生率为25%至50%。本报告调查了MCTD患者的组织病理学表现。本研究对17例MCTD患者进行。在临床特征方面，有6例为肾病综合征，2例为血尿和蛋白尿。除1例（MF病例）外，他们的肾功能均正常。在病理表现方面，有4例为膜性肾病，2例为系膜增生性肾小球肾炎，其中包括1例IgA肾病，11例为轻度肾小球异常。3例在随访期（1至5年）转变为系统性红斑狼疮（SLE）。他们共同的特点是补体降低和膜性肾病。总之，肾病在MCTD患者中并非罕见并发症。17例MCTD患者中有6例（35.3%）患有肾病。伴有免疫复合物性肾小球肾炎的MCTD病例可能会从MCTD转变为SLE。
