Alekberova Z S, Kosheleva N M, Belitskaia S G, Marichik N V
Ter Arkh. 1994;66(10):46-51.
To evaluate the effect of pregnancy on systemic lupus erythematosus (SLE) activity, the authors studied 35 patients with definite SLE (ARA criteria, 1982). SLE activity was estimated every trimester of pregnancy and 3-14 months after the delivery. The disease activity was judged by scores (SLEDAI, version I and II) and by an increase in prednisolone dose more than 5 mg/day. The activity score elevated in 31% (SLEDAI I) or in 17% (SLEDAI II) during pregnancy was similar to frequency of flares after the child's birth (34% or 23%, respectively). In 22 (63%) of 35 patients the steroid dosage was increased during pregnancy versus 3 (8.5%) patients postpartum. The most frequent SLE complications observed in pregnancy were renal, CNS and mucocutaneous disorders. The frequency of SLE exacerbations and outcomes of pregnancy were related to the disease activity in conception.
为评估妊娠对系统性红斑狼疮（SLE）活动的影响，作者研究了35例符合1982年美国风湿病学会（ARA）标准的确诊SLE患者。在妊娠的每个 trimester 以及分娩后3至14个月评估SLE活动情况。通过评分（SLEDAI，第一版和第二版）以及泼尼松龙剂量每日增加超过5mg来判断疾病活动度。妊娠期间活动评分升高者在SLEDAI I中占31%，在SLEDAI II中占17%，这与产后病情复发频率相似（分别为34%和23%）。35例患者中有22例（63%）在妊娠期间增加了类固醇剂量，而产后仅有3例（8.5%）患者增加剂量。妊娠期间观察到的最常见SLE并发症是肾脏、中枢神经系统和皮肤黏膜疾病。SLE病情加重的频率和妊娠结局与受孕时的疾病活动度有关。 （注：trimester在医学语境中常指孕期的三个月，但中文里没有完全对应的简洁词汇，这里直接保留英文便于理解原文含义。）
