普萘洛尔与心得宁治疗甲状腺功能亢进的对比试验。
Comparative trial of propranolol and practolol in hyperthyroidism.
作者信息
Nelson J K, McDevitt D G
出版信息
Br J Clin Pharmacol. 1975 Oct;2(5):411-6. doi: 10.1111/j.1365-2125.1975.tb00549.x.
The possible role of practolol in the management of hyperthyroidism has been studied by comparing it with propranolol. 2. In a double-blind cross-over trial, propranolol (40 mg), practolol (120 mg) and a placebo four times daily for one week were compared in twenty-one hyperthyroid patients by sequential analysis. 3. Judged by their effect on the symptoms and signs of thyrotoxicosis, both propranolol and practolol were significantly better than the placebo but no clear distinction could be made between the two active compounds. 4. Propranolol and practolol reduced heart rate by 24 and 17% respectively compared with placebo. 5. Patients generally preferred propranolol or practolol to placebo but this preference did not achieve significance with either drug. 6. Only in its effect on heart rate was practolol significantly inferior to propranolol, and it would appear to be a useful alternative to propranolol in the management of the peripheral manifestations of hyperthyroidism.
通过将心得宁与普萘洛尔进行比较，研究了心得宁在甲状腺功能亢进症治疗中的可能作用。2. 在一项双盲交叉试验中，通过序贯分析比较了21例甲状腺功能亢进患者每日四次服用普萘洛尔（40毫克）、心得宁（120毫克）和安慰剂，持续一周的效果。3. 从它们对甲状腺毒症症状和体征的影响来看，普萘洛尔和心得宁均明显优于安慰剂，但两种活性化合物之间没有明显区别。4. 与安慰剂相比，普萘洛尔和心得宁分别使心率降低了24%和17%。5. 患者总体上更喜欢普萘洛尔或心得宁而非安慰剂，但这种偏好对两种药物来说均未达到显著水平。6. 仅在对心率的影响方面，心得宁明显不如普萘洛尔，在治疗甲状腺功能亢进症的外周表现方面，它似乎是普萘洛尔的一种有用替代品。
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