Lopez I, Goudou C, Ribrag V, Sauvage C, Hazebroucq G, Dreyfus F
Service Pharmacie-Toxicologie, Groupe Hospitalier Cochin, Paris.
Ann Med Interne (Paris). 1994;145(6):405-8.
Mucositis represents one of the most frequent complications during chemotherapy or radiotherapy. Few studies have showed effective prevention against mucositis in this setting. In this randomized study, we tested the efficacy of vitamin E in the treatment of chemotherapy-induced mucositis. Twenty patients with malignant haemopathies were included; 19 patients were evaluable for the prevention of mucositis. Ten patients were treated with induction therapy for acute myelogenous leukaemia and 9 were treated with intensive therapy followed by autologous bone marrow transplantations. The severity of mucositis was evaluated according to World Health Organization classification. Our results showed that vitamin E may be of therapeutical value in the prevention of mucositis especially during induction therapy for acute myelogenous leukaemia.
黏膜炎是化疗或放疗期间最常见的并发症之一。在这种情况下，很少有研究表明对黏膜炎有有效的预防措施。在这项随机研究中，我们测试了维生素E治疗化疗引起的黏膜炎的疗效。纳入了20例恶性血液病患者；19例患者可评估黏膜炎的预防情况。10例患者接受急性髓性白血病诱导治疗，9例患者接受强化治疗后进行自体骨髓移植。根据世界卫生组织分类评估黏膜炎的严重程度。我们的结果表明，维生素E在预防黏膜炎方面可能具有治疗价值，尤其是在急性髓性白血病诱导治疗期间。
