人类血清素转运体基因的组织
Organization of the human serotonin transporter gene.
作者信息
Lesch K P, Balling U, Gross J, Strauss K, Wolozin B L, Murphy D L, Riederer P
机构信息
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
出版信息
J Neural Transm Gen Sect. 1994;95(2):157-62. doi: 10.1007/BF01276434.
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.
编码人类5-羟色胺转运体（5-HTT）的基因已被分离并进行了特征分析。人类5-HTT基因由14个外显子组成，跨度约为31kb。所有外显子的序列，包括相邻的内含子序列和一个串联重复DNA多态性（VNTR），均已确定，并以登录号X76753至X76762存入EMBL/GenBank数据库。5-HTT基因的特征分析将有助于推进5-羟色胺摄取调节的分子药理学研究，并促进对其在精神疾病中作用的研究。
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