Harasawa R
Animal Center for Biomedical Research, Faculty of Medicine, University of Tokyo, Japan.
J Vet Med Sci. 1994 Oct;56(5):961-4. doi: 10.1292/jvms.56.961.
Comparative analysis of nucleotide sequences in the 5' non-coding region (NCR) of pestivirus RNA detected from live porcine and human virus vaccines indicated that the contaminants are of bovine viral diarrhea virus (BVDV), and that there are at least three genotypes, which are distinct from hog cholera virus, among the BVDV strains. Most of the nucleotide changes in variable regions of the 5' NCR were covariant, with complementary substitutions at other positions for secondary structures. The proposed secondary structure in the 5' NCR was similar to the prokaryotic rho independent terminator. Short open reading frames in the 5' NCR were well conserved among pestiviruses.
对从猪和人类活病毒疫苗中检测到的瘟病毒RNA的5'非编码区（NCR）核苷酸序列进行的比较分析表明，污染物为牛病毒性腹泻病毒（BVDV），并且在BVDV毒株中至少存在三种与猪霍乱病毒不同的基因型。5' NCR可变区的大多数核苷酸变化是协变的，在二级结构的其他位置有互补取代。5' NCR中提议的二级结构类似于原核生物rho非依赖性终止子。瘟病毒之间5' NCR中的短开放阅读框保守性良好。
